Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in abetalipoproteinemia.
نویسندگان
چکیده
منابع مشابه
Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.
To explore the process of lipoprotein assembly, plasmids encoding truncated forms of apolipoprotein B (apoB) were transfected into Chinese hamster ovary (CHO) fibroblasts. (One, encoding apoB53, the N-terminal 53% of apoB100, can direct the assembly and secretion of lipoproteins when expressed in hepatoma cells, while the other, encoding the shorter apoB15, does not direct lipoprotein assembly....
متن کاملTranslocation of Proteins Across the Endoplasmic Reticulum
Translocation-competent microsomal membrane vesicles of dog pancreas were shown to selectively bind nascent, in vitro assembled polysomes synthesizing secretory protein (bovine prolactin) but not those synthesizing cytoplasmic protein (alpha and beta chain of rabbit globin) . This selective polysome binding capacity was abolished when the microsomal vesicles were salt-extracted but was restored...
متن کاملTranslocation of proteins across the endoplasmic reticulum.
Translocation-competent microsomal membrane vesicles of dog pancreas were shown to selectively bind nascent, in vitro assembled polysomes synthesizing secretory protein (bovine prolactin) but not those synthesizing cytoplasmic protein (alpha and beta chain of rabbit globin) . This selective polysome binding capacity was abolished when the microsomal vesicles were salt-extracted but was restored...
متن کاملProtein translocation across the rough endoplasmic reticulum.
The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transp...
متن کاملProtein Translocation Across the Endoplasmic Reticulum Membrane
Proteins to be secreted from eukaryotic cells are delivered to the extracellular space after trafficking through a secretory pathway composed of several complex intracellular compartments. Secretory proteins are first translocated from the cytosol into the endoplasmic reticulum (ER), after which they travel by vesicular trafficking via various intermediate destinations en route to the plasma me...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1996
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)39160-4